This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements). Do not reuse a needle or syringe. They can give you more details about this possible side effect and suggest ways to manage it. Also, its important to brush and floss your teeth regularly while youre using Prolia. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Some people who take Prolia develop severe bone, joint, or muscle pain. The risk is real, but rare. It works with your immune system to help prevent bone loss. You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. Talk with your doctor about which medication is right for you. Prolia is injected under the skin. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). It is not safe to receive Prolia during pregnancy. It may not cover all possible information. Continue reading, While there are no known drug interactions between Prolia (generic name: denosumab) and alcohol, but you should check with your doctor first before you drink. If you have low calcium levels, you should not take Prolia. Results may vary. But if you think youre having a medical emergency, call 911 or your local emergency number. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Your doctor can also advise you on symptoms of low calcium to look for. Theyll discuss with you other treatments to help protect you from fractures and bone loss. This medication guide provides information about the Prolia brand of denosumab. Ask your plan if they cover the drug, and what the cost will be for you. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. Before you have any dental work done, tell your dentist you are receiving this medicine. Our phase IV clinical studies alone cannot establish cause-effect relationship. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. They can recommend a treatment option other than Prolia. This aids in keeping your calcium level within the recommended range. 1 shot every 6 months could mean fewer doses. Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. Doing so will help you avoid the risk for a low calcium level during treatment. Ask your doctor about the pros and cons of using Prolia. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Treating any mouth or dental problems early is the best way to help prevent serious dental complications. But hair loss has been reported by people who have taken Prolia since then. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments But doing so can cause more bone breakdown and increase your risk for bone fractures. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. Women going through menopause have a higher risk of developing osteoporosis. It could harm the unborn baby or cause birth defects. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. What are some frequently asked questions about Prolia? Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments Prescribing Information and If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Can diet help improve depression symptoms? After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. * Sex and gender exist on spectrums. You should also take calcium and vitamin D supplements while being 2023 Healthline Media LLC. Prolia may cause serious side effects. Heres a sample meal plan thats packed with nutritious foods just for. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. Osteoporosis is a condition that causes your bones to become thin and weak. may occur. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. Prolia (denosumab) injection, for subcutaneous use. Peripheral edema is a less common side effect that was reported in clinical studies of females* who received Prolia for osteoporosis after menopause. Be sure to talk with your doctor about your health history before you take Prolia. A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. See what this means for you in the chart below. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. People need calcium for bone health and other functions. Hair loss wasnt reported as a side effect during clinical trials of Prolia. If youre breastfeeding, you should not receive Prolia. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Prolia also carries a warning about hypocalcemia, which is a low level of Adults over age 50 should not exceed 2,000 mg total per day. They need to know if you have any of these conditions: This medicine is for injection under the skin. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Nonmetastatic means the cancer hasnt spread to other areas of the body. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. Use of the term male in this article refers to sex assigned at birth. They may be able to help you identify the cause. Last medically reviewed on November 29, 2022. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Over time, Prolia can reduce bone loss and make your bones stronger. You may wonder how Prolia compares to the medication Zometa. You should not breastfeed while using this medicine. 2023 eHealthMe.com. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. Our website services, content, and products are for informational purposes only. Serious side effects from Prolia can occur, but they arent common. Continue reading, Prolia (denosumab) has not been associated with weight gain in clinical studies. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. DENOSUMAB (den oh sue mab) slows bone breakdown. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. Youll receive Prolia doses from a healthcare professional. For women with osteoporosis after menopause at high risk for fracture. These lists dont include all possible side effects. With low BMD your bone tissues have less mineral, which means they become weaker. All rights reserved. This is because its not known if Prolia is safe to receive while breastfeeding. Do not shake the prefilled syringe. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. RA is an autoimmune condition in which your immune system attacks your joints. The ADA also provides recommendations to help your dentist in reducing your risk for these side effects while youre taking Prolia. Learn more about your health after menopause. A healthcare provider will give you this injection. If youre pregnant or breastfeeding, or considering either, talk with your doctor. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. For more information, you can refer to the drugs prescribing information. Learn how estrogen affects bone health and how you can protect yourself from bone loss, Osteoporosis is more common in women than men, but it affects millions of men every year. Denosumab is contraindicated in women with hypocalcaemia. Continue reading. Motion sickness, nausea, and vomiting can occur as a part of vertigo. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Visit your doctor or health care professional for regular checks on your progress. Do any of yall know? And be sure to let your doctor know about all the medications youre currently taking. If you have serious side effects from Prolia, call your doctor right away. (Vitamin D helps your body absorb calcium.) WebDrug interactions are reported among people who take Prolia and Calcium. This increases your risk for bone fractures. Although its rare, your doctor may give you the option to self-inject Prolia at home. Its important to discuss all your concerns with your doctor. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. Other drugs that have the same active ingredients (e.g. Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. With arthritis, you have pain and inflammation of your joints. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. 8,432 people who take Prolia and Calcium together, and have interactions are studied. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. It may also be higher if you have dental work done while youre taking Prolia. Various types of osteoporosis medications are available. Calcium supplements may help support bone and teeth health. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Most side effects from Prolia are mild and can go away on their own within a few days or weeks. They do this by slowing the loss of minerals such as calcium from your bones. You can learn more about how we ensure our content is accurate and current by reading our. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. Talk to your health care professional or pharmacist for more information. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. You should receive your missed injection as soon as possible. It is important not to miss your dose. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. These types of medications come in forms that are taken by mouth and forms that are given by injection. Specifically, Prolia works by blocking a protein called RANK. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Yoga is an excellent way to manage symptoms of osteoporosis. These factors include what your insurance plan covers. You might like to know how Prolia and the drug Evenity compare.
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